About the role
Who We Are
Cogent Biosciences is a publicly traded biotechnology company focused on developing novel precision therapies to treat a broad range of patients with unmet medical needs. Cogent’s lead program, bezuclastinib, is designed to selectively and potently inhibit exon 17 mutations found within the KIT receptor tyrosine kinase, including KIT D816V. KIT D816V is responsible for driving a rare and serious condition called Systemic Mastocytosis, and exon 17 mutations are also found in patients with gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Bezuclastinib has exhibited promising initial data across all three trials: APEX in AdvSM, SUMMIT in NonAdvSM and PEAK in GIST, including an encouraging safety profile across 600+ patients in single agent and combination dosing.
The Role: This position works in Drug Discovery to provide bioanalytical support for PK, PK/PD, TK, and TGI experiments across multiple programs. The successful candidate will utilize their strong knowledge of LC-MS/MS bioanalysis to quantitate small molecule drugs in biological matrices (plasma primarily). Independent method development, routine bioanalysis, and communication of high-quality data are hallmarks for the position. Maintenance, troubleshooting, and repair of LC-MS/MS instrumentation and software is expected. Secondary roles of the position include providing technical writing support and review as needed.
Responsibilities
- Develop LC-MS/MS methods to quantitate small molecules in biological matrices
- Routine bioanalysis and data release to DMPK project leads
- Maintain, troubleshoot, and repair LC-MS/MS instrumentation and software, including coordination with service engineers for complex matters
- Support technical writing efforts and data QC for preclinical ADME IND efforts
- Good written and oral communication, including timely electronic laboratory notebook entry
- Proven work ethic, competence, enthusiasm, independence, and team focus
Qualifications
- Minimum of BA/BS with 10 years or MS with 8 years of analytical work in Pharma/Biotech
- LC-MS/MS
- Independence, awareness, and multi-tasking in a fast-paced environment
- Scientific and technical knowledge around small molecule quantitative bioanalysis
- Strong knowledge of LC-MS/MS instrumentation, troubleshooting, method development, and quantitation
- Microsoft Office Suite
Preferred Qualifications
- Sciex QQQ or Shimadzu UPLC
- Knowledge of DMPK and relationships of in vitro and in vivo assays
- Non-compartmental PK modeling
- Report writing
- Process automation via software, robotics, or liquid handling
Salary Range
$115,000 - 130,000 USD
Target Bonus: 10-15%
Exact compensation will vary based on skills, experience, and location.
Our Locations
Waltham, MA: Our headquarters is located in the Greater Boston life sciences community, with an open, collaborative office environment designed to support teamwork and connection. Employees benefit from convenient on-site amenities, including free on-site parking and gym facilities in the building.
Boulder, CO: Our Boulder location is home to Cogent’s discovery research organization and a key scientific hub with strong leadership based on site. Situated in the greater Denver-Boulder biopharmaceutical corridor, this office plays a central role in advancing our discovery efforts and pipeline.
Our Offer To You
At Cogent Biosciences, we offer a competitive salary, bonus, and ongoing stock awards, alongside a benefits package that sets us apart. We cover 100% of medical, dental, and vision premiums for you and your family, and help reduce out-of-pocket costs by funding up to 75% of in-network deductibles. Our benefits also include a 401(k) match with immediate vesting, generous paid time off, 12 weeks of fully paid parental leave, paid family and medical leave for all employees regardless of location, and company-paid short-term disability coverage for up to 20 weeks. Additional perks like wellness programs, tuition reimbursement, and inclusive family-forming support help you thrive at work and beyond.
We are proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability, or any other status protected under federal, state, or local law. All employment is decided on the basis of qualifications, merit, and business need.