About the role
Topos Bio
At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.
We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.
What you will do
- Develop and optimize mammalian cell-based assays for disordered protein targets
- Execute phenotypic and reporter-based screening campaigns to validate computational hits
- Characterize compound activity and support structure-activity relationship studies
- Collaborate with computational scientists to integrate experimental data with modeling workflows
- Establish robust assay protocols and quality control metrics
What we are looking for
- Strong foundation in mammalian cell culture and cellular assay development
- Experience with disease-relevant cellular models
- Ability to troubleshoot complex biological systems and optimize experimental protocols
- Track record of productivity and effective collaboration
Preferred
- PhD in cell and molecular biology with focus on disease models
- Industry experience in drug discovery or biotech
- Experience with reporter assays and high-throughput screening platforms
- Familiarity with oncology, neurodegeneration, or metabolic disease models
- Track record of developing novel cellular assays or screening approaches